1. extrapyramidal disorder, parkinsonism, tremor, hypertonia, dystonia, akathisia, dizziness, sedation, somnolence

2. Dizziness, amnesia, ataxia, encephalopathy, facial paralysis, hypertonia, neuropathy, peripheral neuritis, somnolence, tremor, taste perversion, migraine, extrapyramidal syndrome

3. Any mechanism or pharma-cological substance that suppresses the excessive jerks and muscle hypertonia tends also to suppress Clonus

4. The adipose patient declared in his history acute bronchitis and arterial hypertonia, as well as a tachyarrhythmic episode 10 years ago.

5. The ADRs that appeared to be dose-related included weight increased, headache, salivary hypersecretion, vomiting, dyskinesia, akathisia, dystonia, extrapyramidal disorder, hypertonia, and Parkinsonism

6. Investigation of abortion –, premature birth rate, fetal retardation, malformation, hospitalization, modus of labour, birth weight, gestational age, perinatal mortality, hypertonia, preeclampsia, anemia, kidney function, rejection crisis, mechanical compression, kidney function after 1 and 5 years postpartum.

7. The most common treatment-related adverse drug reactions were atrioventricular block, bradycardia, sinus tachycardia, tachycardia, bundle branch block, abdominal pain upper, dry mouth, salivary hypersecretion, vomiting, asthenia, fatigue, weight increased, headache, akathisia, dizziness, dystonia, extrapyramidal disorder, hypertonia, Parkinsonism, sedation, somnolence, tremor and orthostatic hypotension.

8. 3¿ is aryl which may have suitable substituent(s), and A is lower alkylene, or a pharmaceutically acceptable salt thereof, for the treatment of various diseases selected from the group consisting of cardiac hypertrophy, nephropacy such as nephritis or renal failure, arteriosclerosis, obliterans, obstructive thrombus, arterial embolus, Bürger-Grütz syndrome, acrocyanosis, chilblain, frostbite, prolactin-producing ovulation disorder, prolactin-producing pituitary tumor, puerperal galactoschesia, galactorrhea, distal hypertrophy, pituitary gigantism, mental illness, cerebrovascular diseases, tachycardia accompanied by sympathetic hypertonia, hyperaldosteronism, and diabetic complication.